Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles

Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles

Abstract This study investigates methylation patterns in circulating cell-free DNA (ccfDNA) for their potential role in colorectal cancer (CRC) detection and the monitoring of treatment response. Through methylation microarrays and quantitative PCR assays, we analyzed 440 samples from The Cancer Gen...

Full description

Bibliographic Details
Main Authors: Kazuya Yasui, Toshiaki Toshima, Ryo Inada, Yuzo Umeda, Shuya Yano, Hiroaki Tanioka, Akihiro Nyuya, Toshiyoshi Fujiwara, Takeshi Yamada, Yoshio Naomoto, Ajay Goel, Takeshi Nagasaka
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Molecular Cancer
Subjects:
Circulating cell-free DNA
Liquid biopsy
Methylation
Colorectal cancer
Online Access:https://doi.org/10.1186/s12943-023-01910-y

Internet

https://doi.org/10.1186/s12943-023-01910-y

Similar Items