Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study

Abstract Vitamin D deficiency is a candidate risk factor for osteoporosis, characterized by decreased bone mineral density (BMD). We performed this two-sample Mendelian randomization (MR) analysis to investigate the causal effect of vitamin D on BMD. We extracted 143 single-nucleotide polymorphisms...

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Bibliographic Details
Main Authors: Yanchao Tang, Feng Wei, Miao Yu, Hua Zhou, Yongqiang Wang, Zhiyong Cui, Xiaoguang Liu
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-14548-5