Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Abstract Spermatogonial stem cells regenerate and maintain spermatogenesis throughout life, making testis a good model for studying stem cell biology. The effects of chemotherapy on fertility have been well‐documented previously. This study investigates how busulfan, an alkylating agent that is ofte...

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Bibliographic Details
Main Authors: Laura Thirouard, Hélène Holota, Mélusine Monrose, Manon Garcia, Angélique de Haze, Christelle Damon‐Soubeyrand, Yoan Renaud, Jean‐Paul Saru, Alessia Perino, Kristina Schoonjans, Claude Beaudoin, David H. Volle
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Advanced Science
Subjects:
chemodrugs
germ cells
GLIS2
male fertility
stem cell regeneration
TGR5
Online Access:https://doi.org/10.1002/advs.202200626

Internet

https://doi.org/10.1002/advs.202200626

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