Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth.

Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth.

BACKGROUND: Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone lesions, in which bone formation is impaired and osteoclastic bone resorption is enhanced. TGF-beta, a potent inhibitor of terminal osteoblast (OB) differentiation, is abundantly deposited...

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Detalhes bibliográficos
Main Authors: Kyoko Takeuchi, Masahiro Abe, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Shinsuke Kido, Takeshi Harada, Osamu Tanaka, Hirokazu Miki, Shingen Nakamura, Ayako Nakano, Kumiko Kagawa, Kenichiro Yata, Shuji Ozaki, Toshio Matsumoto
Formato: Artigo
Idioma:English
Publicado em: Public Library of Science (PLoS) 2010-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC2845613?pdf=render

Internet

http://europepmc.org/articles/PMC2845613?pdf=render

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