Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth.
BACKGROUND: Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone lesions, in which bone formation is impaired and osteoclastic bone resorption is enhanced. TGF-beta, a potent inhibitor of terminal osteoblast (OB) differentiation, is abundantly deposited...
| Main Authors: | , , , , , , , , , , , , , , |
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| פורמט: | Article |
| שפה: | English |
| יצא לאור: |
Public Library of Science (PLoS)
2010-01-01
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| סדרה: | PLoS ONE |
| גישה מקוונת: | http://europepmc.org/articles/PMC2845613?pdf=render |