Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity

Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity

ObjectiveThere is an urgent need for novel biomarkers in lupus nephritis (LN). We report a non-invasive urinary biomarker, L-selectin, in two independent multi-ethnic cohorts.MethodsuL-selectin was tested cross-sectionally in a Chinese cohort (n=255) and a US cohort (n=219) of SLE patients and contr...

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Bibliographic Details
Main Authors: Yiwei Shen, Kamala Vanarsa, Zhihua Yin, Ting Zhang, Jessica Castillo, Min Dai, Linghua Zou, Ling Qin, Jieying Wang, Qiang Guo, Ramesh Saxena, Michelle Petri, Nan Shen, Zhizhong Ye, Chandra Mohan, Huihua Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
lupus nephritis
L-selectin
urinary biomarker
renal histopathology
treatment response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1200167/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1200167/full

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