Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19

Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19

A transduced mouse model of SARS-CoV-2 infection was established using Balb/c mice. This was achieved through the adenovirus-vectored delivery of the hACE2 gene, to render the mice transiently susceptible to the virus. The model was characterised in terms of the dissemination of hACE2 receptor expre...

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Bibliographic Details
Main Authors: Sophie J. Smither, Sarah Kempster, Simon L. Priestnall, Alejandro Suárez-Bonnet, Helen Stapleton, Thomas R. Laws, Deborah Ferguson, Neil Almond, Mark S. Lever, E. Diane Williamson
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
isolates
mouse model
transduction
virulence
Online Access:https://www.mdpi.com/1999-4915/14/8/1769

Internet

https://www.mdpi.com/1999-4915/14/8/1769

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