SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma

SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma

Son of sevenless 1 and 2 (SOS1 and SOS2) are RAS guanine nucleotide exchange factors (RasGEFs) that mediate physiologic and pathologic receptor tyrosine kinase (RTK)‐dependent RAS activation. Here, we show that SOS2 modulates the threshold of epidermal growth factor receptor (EGFR) signaling to regu...

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Bibliografische gegevens
Hoofdauteurs: Patricia L. Theard, Amanda J. Linke, Nancy E. Sealover, Brianna R. Daley, Johnny Yang, Katherine Cox, Robert L. Kortum
Formaat: Artikel
Taal:English
Gepubliceerd in: Wiley 2024-03-01
Reeks:Molecular Oncology
Onderwerpen:
acquired resistance
EGFR‐TKI
osimertinib
PI3K
RAS
SOS2
Online toegang:https://doi.org/10.1002/1878-0261.13564

Internet

https://doi.org/10.1002/1878-0261.13564

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