SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma

SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma

Son of sevenless 1 and 2 (SOS1 and SOS2) are RAS guanine nucleotide exchange factors (RasGEFs) that mediate physiologic and pathologic receptor tyrosine kinase (RTK)‐dependent RAS activation. Here, we show that SOS2 modulates the threshold of epidermal growth factor receptor (EGFR) signaling to regu...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Patricia L. Theard, Amanda J. Linke, Nancy E. Sealover, Brianna R. Daley, Johnny Yang, Katherine Cox, Robert L. Kortum
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Wiley 2024-03-01
Ráidu:Molecular Oncology
Fáttát:
acquired resistance
EGFR‐TKI
osimertinib
PI3K
RAS
SOS2
Liŋkkat:https://doi.org/10.1002/1878-0261.13564

Interneahtta

https://doi.org/10.1002/1878-0261.13564

Geahča maid