SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma

SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma

Son of sevenless 1 and 2 (SOS1 and SOS2) are RAS guanine nucleotide exchange factors (RasGEFs) that mediate physiologic and pathologic receptor tyrosine kinase (RTK)‐dependent RAS activation. Here, we show that SOS2 modulates the threshold of epidermal growth factor receptor (EGFR) signaling to regu...

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Bibliographic Details
Main Authors: Patricia L. Theard, Amanda J. Linke, Nancy E. Sealover, Brianna R. Daley, Johnny Yang, Katherine Cox, Robert L. Kortum
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Molecular Oncology
Subjects:
acquired resistance
EGFR‐TKI
osimertinib
PI3K
RAS
SOS2
Online Access:https://doi.org/10.1002/1878-0261.13564

Internet

https://doi.org/10.1002/1878-0261.13564

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