Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications

Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications

Summary: A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 (COVID-19). The interaction between SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2) triggers the activation of th...

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Bibliographic Details
Main Authors: Nicola Potere, Marco Giuseppe Del Buono, Roberto Caricchio, Paul C. Cremer, Alessandra Vecchié, Ettore Porreca, Daniela Dalla Gasperina, Francesco Dentali, Antonio Abbate, Aldo Bonaventura
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
COVID-19
NLRP3 inflammasome
IL-1β
IL-18
C-reactive protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422004819

Internet

http://www.sciencedirect.com/science/article/pii/S2352396422004819

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