Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

Summary: A functional electron transport chain (ETC) is crucial for supporting bioenergetics and biosynthesis. Accordingly, ETC inhibition decreases proliferation in cancer cells but does not seem to impair stem cell proliferation. However, it remains unclear how stem cells metabolically adapt. In t...

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Bibliographic Details
Main Authors: Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Gianmarco Rinaldi, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquière, Bernard Thienpont, Sarah-Maria Fendt, Nick van Gastel, Geert Carmeliet
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472200907X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472200907X

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