Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Staphylococcus aureus Osteomyelitis

Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Staphylococcus aureus Osteomyelitis

Staphylococcus aureus is the predominant pathogen causing osteomyelitis. Unfortunately, no immunotherapy exists to treat these very challenging and costly infections despite decades of research, and numerous vaccine failures in clinical trials. This lack of success can partially be attributed to an...

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Bibliographic Details
Main Authors: Gowrishankar Muthukrishnan, Alexandra Wallimann, Javier Rangel-Moreno, Karen L. de Mesy Bentley, Maria Hildebrand, Karen Mys, H. Mark Kenney, Eric T. Sumrall, John L. Daiss, Stephan Zeiter, R. Geoff Richards, Edward M. Schwarz, T. Fintan Moriarty
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
humanized mice
Staphylococcus aureus
bone infection
osteolysis
staphylococcal abscess communities
T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.651515/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.651515/full

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