Immature O-glycans recognized by the macrophage glycoreceptor CLEC10A (MGL) are induced by 4-hydroxy-tamoxifen, oxidative stress and DNA-damage in breast cancer cells

Immature O-glycans recognized by the macrophage glycoreceptor CLEC10A (MGL) are induced by 4-hydroxy-tamoxifen, oxidative stress and DNA-damage in breast cancer cells

Abstract Background Ligands of the C-type lectin CLEC10A such as Tn and sialyl-Tn representing early intermediates of O-glycosylation are hallmarks of many human malignancies. A variety of regulatory mechanisms underlying their expression are being discussed. Methods CLEC10A ligands were detected in...

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Bibliographic Details
Main Authors: Anna-Katharina Kurze, Sophia Buhs, Dennis Eggert, Leticia Oliveira-Ferrer, Volkmar Müller, Axel Niendorf, Christoph Wagener, Peter Nollau
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
Hormone dependence
O-glycosylation
Tn-antigen
Online Access:http://link.springer.com/article/10.1186/s12964-019-0420-9

Internet

http://link.springer.com/article/10.1186/s12964-019-0420-9

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