Differential properties of KRAS transversion and transition mutations in non-small cell lung cancer: associations with environmental factors and clinical outcomes

Differential properties of KRAS transversion and transition mutations in non-small cell lung cancer: associations with environmental factors and clinical outcomes

Abstract Background KRAS-mutated non-small cell lung cancer (NSCLC) accounts for 23–35% and 13–20% of all NSCLCs in white patients and East Asians, respectively, and is therefore regarded as a major therapeutic target. However, its epidemiology and clinical characteristics have not been fully elucid...

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Main Authors: Koichi Sato, Hiroaki Akamatsu, Yasuhiro Koh, Koichi Ogawa, Shun-ichi Isa, Masahiko Ando, Akihiro Tamiya, Akihito Kubo, Chiyoe Kitagawa, Tomoya Kawaguchi, Nobuyuki Yamamoto
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Cancer
Subjects:
KRAS
Transversion
Transition
Smoking
Environmental factors
Non-small cell lung cancer
Online Access:https://doi.org/10.1186/s12885-022-10246-7

Internet

https://doi.org/10.1186/s12885-022-10246-7

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