Pixantrone Sensitizes Gram-Negative Pathogens to Rifampin

Pixantrone Sensitizes Gram-Negative Pathogens to Rifampin

ABSTRACT The emergence of bacterial drug resistance poses a severe threat to global public health. In particular, antimicrobial-resistant pathogens lead to a high rate of treatment failure and significantly increase mortality. Repurposing FDA-approved compounds to sensitize superbugs to conventional...

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Bibliographic Details
Main Authors: Pengfei She, Zehao Li, Yimin Li, Shasha Liu, Linhui Li, Yifan Yang, Linying Zhou, Yong Wu
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
drug repurposing
Gram-negative pathogen
pixantrone
proton motive force
reactive oxygen species
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02114-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02114-22

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