5-Aminolevulinic acid protects against cisplatin-induced nephrotoxicity without compromising the anticancer efficiency of cisplatin in rats in vitro and in vivo.

5-Aminolevulinic acid protects against cisplatin-induced nephrotoxicity without compromising the anticancer efficiency of cisplatin in rats in vitro and in vivo.

Nephrotoxicity is a frequent and major limitation in cisplatin (CDDP)-based chemotherapy. 5-Aminolevulinic acid (ALA) is widely distributed in animal cells, and it is a precursor of tetrapyrole compounds such as heme that is fundamentally important in aerobic energy metabolism. The aim of this study...

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Bibliographic Details
Main Authors: Yoshio Terada, Keiji Inoue, Tatsuki Matsumoto, Masayuki Ishihara, Kazu Hamada, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue, Yoshinori Taniguchi, Taro Horino, Takashi Karashima, Kenji Tamura, Hideo Fukuhara, Shimpei Fujimoto, Masayuki Tsuda, Taro Shuin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3855642?pdf=render

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http://europepmc.org/articles/PMC3855642?pdf=render

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