Lynch Syndrome Germline Mutations in Breast Cancer: Next Generation Sequencing Case-Control Study of 1,263 Participants

Lynch Syndrome Germline Mutations in Breast Cancer: Next Generation Sequencing Case-Control Study of 1,263 Participants

Genome instability—the increased tendency of acquiring mutations in the genome and ability of a cell to tolerate high mutation burden—is one of the drivers of cancer. Genome instability results from many causes including defects in DNA repair systems. Previously, it has been shown that germline path...

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Bibliographic Details
Main Authors: Aleksey G. Nikitin, Daria A. Chudakova, Rafael F. Enikeev, Dina Sakaeva, Maxim Druzhkov, Leyla H. Shigapova, Olga I. Brovkina, Elena I. Shagimardanova, Oleg A. Gusev, Marat G. Gordiev
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
breast cancer
EPCAM
Lynch syndrome
MLH1
MSH2
MSH6
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00666/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00666/full

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