Prognostic stratification based on HIF-1α signaling for evaluating hypoxia status and immune landscape in hepatocellular carcinoma

Prognostic stratification based on HIF-1α signaling for evaluating hypoxia status and immune landscape in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) has a desmoplastic and hypoxic tumor microenvironment (TME), resulting in poor prognosis and treatment resistance. This study aimed to construct a novel prognostic classifier to investigate the degree of hypoxia and immune profiles in HCC. Patients with HCC fr...

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Bibliographic Details
Main Authors: Hongkai Zhuang, Zedan Zhang, Bo Chen, Chenwei Tang, Xinming Chen, Wenliang Tan, Lei Yang, Zhiqin Xie, Xiaowu Ma, Qingbin Wang, Bingkun Wang, Changzhen Shang, Yajin Chen
Format: Article
Language:English
Published: SpringerOpen 2023-05-01
Series:Journal of Big Data
Subjects:
Hepatocellular carcinoma
HIF-1α
Hypoxia
Immune checkpoint blockade
Overall survival
Transcatheter arterial chemoembolization
Online Access:https://doi.org/10.1186/s40537-023-00752-1

Internet

https://doi.org/10.1186/s40537-023-00752-1

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