Synthesis and Biological Investigation of Bile Acid-Paclitaxel Hybrids

Synthesis and Biological Investigation of Bile Acid-Paclitaxel Hybrids

Chenodeoxycholic acid and ursodeoxycholic acid (CDCA and UDCA, respectively) have been conjugated with paclitaxel (PTX) anticancer drugs through a high-yield condensation reaction. Bile acid-PTX hybrids (BA-PTX) have been investigated for their pro-apoptotic activity towards a selection of cancer ce...

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Bibliographic Details
Main Authors: Elisabetta Melloni, Elena Marchesi, Lorenzo Preti, Fabio Casciano, Erika Rimondi, Arianna Romani, Paola Secchiero, Maria Luisa Navacchia, Daniela Perrone
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
bile acids
paclitaxel
ursodeoxycholic acid
chenodeoxycholic acid conjugation
pacific blue
hybrids drugs
Online Access:https://www.mdpi.com/1420-3049/27/2/471

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https://www.mdpi.com/1420-3049/27/2/471

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