The SAMHD1-MX2 axis restricts HIV-1 infection at postviral DNA synthesis

The SAMHD1-MX2 axis restricts HIV-1 infection at postviral DNA synthesis

ABSTRACT HIV-1 replication is tightly regulated in host cells, and various restriction factors have important roles in inhibiting viral replication. SAMHD1, a well-known restriction factor, suppresses HIV-1 replication by hydrolyzing intracellular dNTPs, thereby limiting the synthesis of viral cDNA...

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Bibliographic Details
Main Authors: Haoran Guo, Wanying Yang, Huili Li, Jiaxin Yang, Yuehan Huang, Yubin Tang, Shijin Wang, Fushun Ni, Weiming Yang, Xiao-Fang Yu, Wei Wei
Format: Article
Language:English
Published: American Society for Microbiology 2024-07-01
Series:mBio
Subjects:
SAMHD1
MX2/MxB
HIV
antiviral immune defense
interferons
Online Access:https://journals.asm.org/doi/10.1128/mbio.01363-24

Internet

https://journals.asm.org/doi/10.1128/mbio.01363-24

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