Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously

Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously

Abstract Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to inductive medium. However, the underlying mechanisms remain obscure. Here we report that self-renewing hnPSCs spontaneously and efficiently give rise to blastoids upon t...

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Bibliographic Details
Main Authors: Mingyue Guo, Jinyi Wu, Chuanxin Chen, Xinggu Wang, An Gong, Wei Guan, Rowan M. Karvas, Kexin Wang, Mingwei Min, Yixuan Wang, Thorold W. Theunissen, Shaorong Gao, José C. R. Silva
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44969-x

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https://doi.org/10.1038/s41467-024-44969-x

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