IPF-Fibroblast Erk1/2 Activity Is Independent from microRNA Cluster 17-92 but Can Be Inhibited by Treprostinil through DUSP1

IPF-Fibroblast Erk1/2 Activity Is Independent from microRNA Cluster 17-92 but Can Be Inhibited by Treprostinil through DUSP1

Idiopathic pulmonary fibrosis (IPF) is a progressive terminal lung disease, and therapies aim to block fibrosis. Fibroblast proliferation is controlled by C/EBP-β, microRNA cluster 17-92 (miR17-92), and Erk1/2 mitogen-activated protein kinase. This study assessed the role of miR17-92 in IPF-fibrobla...

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Bibliographic Details
Main Authors: Sabrina Blumer, Lei Fang, Wei-Chih Chen, Petra Khan, Katrin Hostettler, Michael Tamm, Michael Roth, Christopher Lambers
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
idiopathic pulmonary fibrosis
fibroblast
transforming growth factor β1
platelet-derived growth factor-BB
Erk1/2 mitogen-activated protein kinase
dual specificity phosphatase 1
Online Access:https://www.mdpi.com/2073-4409/10/11/2836

Internet

https://www.mdpi.com/2073-4409/10/11/2836

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