Desensitizing nicotinic agents normalize tinnitus-related inhibitory dysfunction in the auditory cortex and ameliorate behavioral evidence of tinnitus

Desensitizing nicotinic agents normalize tinnitus-related inhibitory dysfunction in the auditory cortex and ameliorate behavioral evidence of tinnitus

Tinnitus impacts between 10–20% of the population. Individuals most troubled by their tinnitus have their attention bound to and are distracted by, their tinnitus percept. While numerous treatments to ameliorate tinnitus have been tried, no therapeutic approach has been clinically accepted. The pres...

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Bibliographic Details
Main Authors: Madan Ghimire, Rui Cai, Lynne Ling, Kevin A. Brownell, Kurt W. Wisner, Brandon C. Cox, Troy A. Hackett, Thomas J. Brozoski, Donald M. Caspary
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Neuroscience
Subjects:
tinnitus
nicotinic cholinergic receptor
primary auditory cortex
pyramidal neuron
VIP neuron
sazetidine-A
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1197909/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1197909/full

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