Optimization of Mouse Growth Hormone Plasmid DNA Electrotransfer into Tibialis Cranialis Muscle of “Little” Mice

Optimization of Mouse Growth Hormone Plasmid DNA Electrotransfer into Tibialis Cranialis Muscle of “Little” Mice

Previous non-viral gene therapy was directed towards two animal models of dwarfism: Immunodeficient (lit/scid) and immunocompetent (lit/lit) dwarf mice. The former, based on hGH DNA administration into muscle, performed better, while the latter, a homologous model based on mGH DNA, was less efficien...

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Bibliographic Details
Main Authors: Eliana Rosa Lima, Claudia Regina Cecchi, Eliza Higuti, Gustavo Protasio Pacheco de Jesus, Alissandra Moura Gomes, Enio Aparecido Zacarias, Paolo Bartolini, Cibele Nunes Peroni
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
electrotransfer
gene therapy
homologous model
mIGF-1
little mice
mouse growth hormone
Online Access:https://www.mdpi.com/1420-3049/25/21/5034

Internet

https://www.mdpi.com/1420-3049/25/21/5034

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