Hepatic toxicity caused by PLGA-microspheres containing usnic acid from the lichen C ladonia substellata (AHTI) during pregnancy in Wistar rats

Hepatic toxicity caused by PLGA-microspheres containing usnic acid from the lichen C ladonia substellata (AHTI) during pregnancy in Wistar rats

ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group...

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Bibliographic Details
Main Authors: KETSIA S.N. MARINHO, ERIVALDO A. ANTONIO, CAMILLA V.N.S. SILVA, KEILA T. DA SILVA, VALÉRIA W. TEIXEIRA, FRANCISCO C.A. DE AGUIAR JUNIOR, KATHARINE R.P. DOS SANTOS, NICÁCIO H. DA SILVA, NOEMIA P.S. SANTOS
Format: Article
Language:English
Published: Academia Brasileira de Ciências
Series:Anais da Academia Brasileira de Ciências
Subjects:
encapsulation
fetotoxicity
hepatotoxicity
secondary metabolite
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301073&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301073&lng=en&tlng=en

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