Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A

Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A

The maintenance of human mitochondrial DNA (mtDNA) is critical for proper cellular function as damage to mtDNA, if left unrepaired, can lead to a diverse array of pathologies. Of the pathways identified to participate in DNA repair within the mitochondria, base excision repair (BER) is the most exte...

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Bibliographic Details
Main Authors: Nidhi Sharma, Marlo K. Thompson, Jennifer F. Arrington, Dava M. Terry, Srinivas Chakravarthy, Peter E. Prevelige, Aishwarya Prakash
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
base excision repair (BER)
NEIL1 DNA glycosylase
mitochondrial transcription factor A (TFAM)
small angle X-ray scattering (SAXS)
HDX-MS (hydrogen–deuterium exchange mass-spectrometry)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.893806/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.893806/full

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