Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis

Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis

Abstract Background Recent studies using single-cell transcriptomic analysis have reported several distinct clusters of neoplastic epithelial cells and cancer-associated fibroblasts in the pancreatic cancer tumor microenvironment. However, their molecular characteristics and biological significance...

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Bibliographic Details
Main Authors: Seongryong Kim, Galam Leem, Junjeong Choi, Yongjun Koh, Suho Lee, Sang-Hee Nam, Jin Su Kim, Chan Hee Park, Ho Kyoung Hwang, Kyoung Il Min, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Eui-Cheol Shin, Chang Moo Kang, Seungmin Bang, Jong-Eun Park
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Medicine
Subjects:
Pancreatic cancer
Pancreatic cancer cells
Transitional cell state
Molecular subtype of pancreatic cancer
Cancer-associated fibroblasts
Online Access:https://doi.org/10.1186/s13073-024-01287-7

Internet

https://doi.org/10.1186/s13073-024-01287-7

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