Regulating Th17/Treg Balance Contributes to the Therapeutic Effect of Ziyuglycoside I on Collagen-Induced Arthritis

Regulating Th17/Treg Balance Contributes to the Therapeutic Effect of Ziyuglycoside I on Collagen-Induced Arthritis

To investigate the therapeutic effect and primary pharmacological mechanism of Ziyuglycoside I (Ziyu I) on collagen-induced arthritis (CIA) mice. CIA mice were treated with 5, 10, or 20 mg/kg of Ziyu I or 2 mg/kg of methotrexate (MTX), and clinical manifestations, as well as pathological changes, we...

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Bibliographic Details
Main Authors: Manman Wang, Tiantian Su, Hanfei Sun, Huijuan Cheng, Chunru Jiang, Paipai Guo, Zhenduo Zhu, Ruhong Fang, Feng He, Mingli Ge, Qiuyun Guan, Wei Wei, Qingtong Wang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
rheumatoid arthritis
Th17/Treg
Ziyuglycoside I
mTOR
RORγt
Foxp3
Online Access:https://www.mdpi.com/1422-0067/23/24/16105

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https://www.mdpi.com/1422-0067/23/24/16105

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