Dissecting the effects of METTL3 on alternative splicing in prostate cancer

Dissecting the effects of METTL3 on alternative splicing in prostate cancer

Although the role of METTL3 has been extensively studied in many cancers, its role in isoform switching in prostate cancer (PCa) has been poorly explored. To investigate its role, we applied standard RNA-sequencing and long-read direct RNA-sequencing from Oxford Nanopore to examine how METTL3 affect...

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Bibliographic Details
Main Authors: Lin Wang, Ling Shi, Yonghao Liang, Judy Kin-Wing Ng, Chan Hoi Yin, Lingyi Wang, Jinpao Hou, Yiwei Wang, Cathy Sin-Hang Fung, Peter Ka-Fung Chiu, Chi-Fai Ng, Stephen Kwok-Wing Tsui
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Oncology
Subjects:
METTL3
prostate cancer
RNA splicing
N 6 -methyladenosine
MKNK2
nanopore direct RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1227016/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1227016/full

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