Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression

Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression

Abstract Background To clarify the effects of cylcin E1 expression on HCC tumor progression, we studied the expression of cyclin E1 and inhibitory efficacy of regorafenib and sorafenib in HCC cells, and investigated a potential therapy that combines regorafenib treatment with cyclin E1 inhibition. M...

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Bibliographic Details
Main Authors: Jianliang Xu, Fei Huang, Zhicheng Yao, Changchang Jia, Zhiyong Xiong, Hao Liang, Nan Lin, Meihai Deng
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cell Communication and Signaling
Subjects:
Cyclin E1
Hepatocellular carcinoma
Regorafenib
Mcl-1
Online Access:http://link.springer.com/article/10.1186/s12964-019-0398-3

Internet

http://link.springer.com/article/10.1186/s12964-019-0398-3

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