Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease

Huntington's disease (HD) is caused by a progressive loss of striatal medium spiny neurons (MSN). The molecular trigger of HD is a polyglutamine expansion in the Huntingtin protein (Htt). The mutant Htt protein forms insoluble nuclear aggregates which have been proposed to play a key role in ca...

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Bibliographic Details
Main Authors: Hua Zhang, Qin Li, Rona K. Graham, Elizabeth Slow, Michael R. Hayden, Ilya Bezprozvanny
Format: Article
Language:English
Published: Elsevier 2008-07-01
Series:Neurobiology of Disease
Subjects:
Calcium
NMDAR
Huntington's disease
Transgenic mouse
Mitochondria
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000661

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http://www.sciencedirect.com/science/article/pii/S0969996108000661

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