Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4+ T-cells and induction of antitumor CD8+ T-cell activity

Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4+ T-cells and induction of antitumor CD8+ T-cell activity

An oral sustained-release formulation of Interleukin-10 suppressed tumor growth and enhanced survival in the APCmin/+/Bacteroides fragilis spontaneous colon cancer model. Therapeutic benefit was associated with a 5-fold reduction in CD4+RORγt+Foxp3−IL-17+ T-helper cell, CD4+RORγt+Foxp3+IL-17+ pathog...

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Bibliographic Details
Main Authors: Tao Gu, Magdia De Jesus, Heather C. Gallagher, Thomas P. Burris, Nejat K. Egilmez
Format: Article
Language:English
Published: Taylor & Francis Group 2017-06-01
Series:OncoImmunology
Subjects:
colon cancer
il-10
inflammation
oral micro/nanoparticles
t-cells
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1319027

Internet

http://dx.doi.org/10.1080/2162402X.2017.1319027

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