Integrated functional and spatial profiling of tumour immune responses induced by immunotherapy: the iPROFILER platform

Integrated functional and spatial profiling of tumour immune responses induced by immunotherapy: the iPROFILER platform

Background: Cancer immunotherapy elicits functional activation and changes in immune cell distribution in cancer. Tumour heterogeneity is a reason for treatment failure but is difficult to capture in experimental settings. This proof-of-principle study describes the integrated functional and digital...

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Bibliographic Details
Main Authors: V.H. Koelzer, P. Herzig, I. Zlobec, V. Heinzelmann, D. Lardinois, E. Walseng, C. Rader, K.D. Mertz, A. Zippelius, D.S. Thommen
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Immuno-Oncology and Technology
Subjects:
Ex-vivo models
tumour biomarkers
immunotherapy
digital pathology
computer-assisted image processing
tumour microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2590018821000095

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http://www.sciencedirect.com/science/article/pii/S2590018821000095

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