The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes

The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes

Abstract Background Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the central nervous system (CNS) is implicated in the pathogenesis of neurological diseases such as neuromyelitis optica spectrum disorders or cerebral interferonopathies, respectively. Transgenic mi...

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Bibliographic Details
Main Authors: Phillip K. West, Andrew N. McCorkindale, Boris Guennewig, Thomas M. Ashhurst, Barney Viengkhou, Emina Hayashida, So Ri Jung, Oleg Butovsky, Iain L. Campbell, Markus J. Hofer
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Interleukin-6
Interferon-alpha
Cytokine
Phenotype
Central nervous system
Online Access:https://doi.org/10.1186/s12974-022-02441-x

Internet

https://doi.org/10.1186/s12974-022-02441-x

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