PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair.

PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair.

Replication fork reversal which restrains DNA replication progression is an important protective mechanism in response to replication stress. PARP1 is recruited to stalled forks to restrain DNA replication. However, PARP1 has no helicase activity, and the mechanism through which PARP1 participates i...

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Bibliographic Details
Main Authors: Yen-Chih Ho, Chen-Syun Ku, Siang-Sheng Tsai, Jia-Lin Shiu, Yi-Zhen Jiang, Hui Emmanuela Miriam, Han-Wen Zhang, Yen-Tzu Chen, Wen-Tai Chiu, Song-Bin Chang, Che-Hung Shen, Kyungjae Myung, Peter Chi, Hungjiun Liaw
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010545

Internet

https://doi.org/10.1371/journal.pgen.1010545

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