Determining the defining lengths between mature microRNAs/small interfering RNAs and tinyRNAs

Abstract MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are loaded into Argonaute (AGO) proteins, forming RNA-induced silencing complexes (RISCs). The assembly process establishes the seed, central, 3′ supplementary, and tail regions across the loaded guide, enabling the RISC to recognize ta...

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Bibliographic Details
Main Authors: GeunYoung Sim, Audrey C. Kehling, Mi Seul Park, Cameron Divoky, Huaqun Zhang, Nipun Malhotra, Jackson Secor, Kotaro Nakanishi
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-46562-6