The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis

The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis

ABSTRACT Candida species are among the most prevalent causes of systemic fungal infection, posing a growing threat to public health. While Candida albicans is the most common etiological agent of systemic candidiasis, the frequency of infections caused by non-albicans Candida species is rising. Amon...

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Bibliographic Details
Main Authors: Emily Puumala, Olga Zaslaver, Amy Chen, Dustin Duncan, Meea Fogal, Rebecca S. Shapiro, Mohammad T. Mazhab-Jafari, Luke Whitesell, J. Rafael Montenegro-Burke, Nicole Robbins, Leah E. Cowen
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
Candida albicans
Candida auris
HAL9
HSP12
Pathogen Box
experimental evolution
Online Access:https://journals.asm.org/doi/10.1128/mbio.02730-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02730-22

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