ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis

ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis

Inducible T cell co-stimulator (ICOS), an immune checkpoint protein expressed on activated T cells and its unique ligand, ICOSL, which is expressed on antigen-presenting cells and non-hematopoietic cells, have been extensively investigated in the immune response. Recent findings showed that a solubl...

Full description

Bibliographic Details
Main Authors: Gustavo Ferreira Alves, Ian Stoppa, Eleonora Aimaretti, Chiara Monge, Raffaella Mastrocola, Elisa Porchietto, Giacomo Einaudi, Debora Collotta, Ilaria Bertocchi, Elena Boggio, Casimiro Luca Gigliotti, Nausicaa Clemente, Manuela Aragno, Daniel Fernandes, Carlo Cifani, Christoph Thiemermann, Chiara Dianzani, Umberto Dianzani, Massimo Collino
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
sepsis
inflammation
ICOS (inducible co-stimulatory molecule)
cecal ligation and puncture
osteopontin (OPN)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.992614/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.992614/full

Similar Items