Monocyte Activation Test (MAT) as a possibility of replacement for the rabbit pyrogen test in hyperimmune sera

Monocyte Activation Test (MAT) as a possibility of replacement for the rabbit pyrogen test in hyperimmune sera

ABSTRACT The use of a commercial kit for the monocyte-activation test (MAT) was evaluated for assessing pyrogenic contamination of hyperimmune sera . Three batches of sera, two pyrogen free and one pyrogenic, were tested. Endotoxin spike recover indicated that sample dilutions from 1/2 to 1/10 are s...

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Bibliographic Details
Main Authors: Carla Lilian de Agostini Utescher, Klariane Laís Buosi, Viviane Fungaro Botosso, Wagner Quintilio
Format: Article
Language:English
Published: Universidade de São Paulo 2018-07-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Monocytes Activation Test
Pyrogen
Hyperimmune serum
Pyrodetect kit
Cryoblood.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200605&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200605&lng=en&tlng=en

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