Dual CSF1R inhibition and CD40 activation demonstrates anti-tumor activity in a 3D macrophage- HER2+ breast cancer spheroid model

Dual CSF1R inhibition and CD40 activation demonstrates anti-tumor activity in a 3D macrophage- HER2+ breast cancer spheroid model

The complex interaction between tumor-associated macrophages (TAMs) and tumor cells through soluble factors provides essential cues for breast cancer progression. TAMs-targeted therapies have shown promising clinical therapeutical potential against cancer progression. The molecular mechanisms underl...

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Bibliographic Details
Main Authors: Manuel Rodriguez-Perdigon, Laetitia Haeni, Barbara Rothen-Rutishauser, Curzio Rüegg
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
breast cancer
macrophages
spheroids
3D model
cancer immunotherapy
CD40
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1159819/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1159819/full

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