SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence

SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence

Human corneal endothelial cells (hCECs) are restricted in proliferative capacity in vivo. Reduction in the number of hCEC leads to persistent corneal edema requiring corneal transplantation. This study demonstrates the functions of SIRT1 in hCECs and its potential for corneal endothelial regeneratio...

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Bibliographic Details
Main Authors: Hye Jun Joo, Dae Joong Ma, Jin Sun Hwang, Young Joo Shin
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antioxidants
Subjects:
SIRT1
corneal endothelial cells
senescence
CRISPR/dCas9
Online Access:https://www.mdpi.com/2076-3921/9/11/1085

Internet

https://www.mdpi.com/2076-3921/9/11/1085

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