SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence

SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence

Human corneal endothelial cells (hCECs) are restricted in proliferative capacity in vivo. Reduction in the number of hCEC leads to persistent corneal edema requiring corneal transplantation. This study demonstrates the functions of SIRT1 in hCECs and its potential for corneal endothelial regeneratio...

Detaylı Bibliyografya
Asıl Yazarlar:	Hye Jun Joo, Dae Joong Ma, Jin Sun Hwang, Young Joo Shin
Materyal Türü:	Makale
Dil:	English
Baskı/Yayın Bilgisi:	MDPI AG 2020-11-01
Seri Bilgileri:	Antioxidants
Konular:	SIRT1 corneal endothelial cells senescence CRISPR/dCas9
Online Erişim:	https://www.mdpi.com/2076-3921/9/11/1085

Benzer Materyaller

From DNA-protein interactions to the genetic circuit design using CRISPR-dCas systems
Yazar:: A. K. Shaytan, ve diğerleri
Baskı/Yayın Bilgisi: (2022-12-01)

Live imaging and tracking of genome regions in CRISPR/dCas9 knock-in mice
Yazar:: Jinzhi Duan, ve diğerleri
Baskı/Yayın Bilgisi: (2018-11-01)

Deciphering Plant Chromatin Regulation via CRISPR/dCas9-Based Epigenome Engineering
Yazar:: Annick Dubois, ve diğerleri
Baskı/Yayın Bilgisi: (2021-08-01)

CRISPR/dCas9-Mediated Parkin Inhibition Impairs Mitophagy and Aggravates Apoptosis of Rat Nucleus Pulposus Cells Under Oxidative Stress
Yazar:: Tao Lan, ve diğerleri
Baskı/Yayın Bilgisi: (2021-04-01)

CRISPR/dCas9-Based Systems: Mechanisms and Applications in Plant Sciences
Yazar:: Chou Khai Soong Karlson, ve diğerleri
Baskı/Yayın Bilgisi: (2021-09-01)

Comparison and optimization of CRISPR/dCas9/gRNA genome-labeling systems for live cell imaging
Yazar:: Yu Hong, ve diğerleri
Baskı/Yayın Bilgisi: (2018-03-01)

Targeted eradication of EBV-positive cancer cells by CRISPR/dCas9-mediated EBV reactivation in combination with ganciclovir
Yazar:: Febri Gunawan Sugiokto, ve diğerleri
Baskı/Yayın Bilgisi: (2024-07-01)

CRISPR/dCas9-Mediated Gene Silencing in Two Plant Fungal Pathogens
Yazar:: Yun-mu Zhang, ve diğerleri
Baskı/Yayın Bilgisi: (2023-02-01)

CRISPR-dCas9-Based Artificial Transcription Factors to Improve Efficacy of Cancer Treatment With Drug Repurposing: Proposal for Future Research
Yazar:: Alejandro Martinez-Escobar, ve diğerleri
Baskı/Yayın Bilgisi: (2021-02-01)

CKM and TERT dual promoters drive CRISPR–dCas9 to specifically inhibit the malignant behavior of osteosarcoma cells
Yazar:: Yawei Hu, ve diğerleri
Baskı/Yayın Bilgisi: (2023-07-01)

Knockdown of Long Non-coding RNA SNGH3 by CRISPR-dCas9 Inhibits the Progression of Bladder Cancer
Yazar:: Yu Cao, ve diğerleri
Baskı/Yayın Bilgisi: (2021-03-01)

Increasing Specificity of Targeted DNA Methylation Editing by Non-Enzymatic CRISPR/dCas9-Based Steric Hindrance
Yazar:: Daniel M. Sapozhnikov, ve diğerleri
Baskı/Yayın Bilgisi: (2023-04-01)

The CRISPR-dCas9 interference system suppresses inhA gene expression in Mycobacterium smegmatis
Yazar:: Nuntita Singpanomchai, ve diğerleri
Baskı/Yayın Bilgisi: (2024-10-01)

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner
Yazar:: Henriette O’Geen, ve diğerleri
Baskı/Yayın Bilgisi: (2019-05-01)

The dCas9-based genome editing in Plasmodium yoelii
Yazar:: Chao Zhang, ve diğerleri
Baskı/Yayın Bilgisi: (2024-03-01)

Up-Regulating ERIC by CRISPR-dCas9-VPR Inhibits Cell Proliferation and Invasion and Promotes Apoptosis in Human Bladder Cancer
Yazar:: Jiangeng Yang, ve diğerleri
Baskı/Yayın Bilgisi: (2021-03-01)

Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
Yazar:: Yi Yang, ve diğerleri
Baskı/Yayın Bilgisi: (2023-11-01)

Engineering Synthetic Signaling Pathways with Programmable dCas9-Based Chimeric Receptors
Yazar:: Toni A. Baeumler, ve diğerleri
Baskı/Yayın Bilgisi: (2017-09-01)

Activation of Insulin Gene Expression via Transfection of a CRISPR/dCas9a System Using Magnetic Peptide-Imprinted Nanoparticles
Yazar:: Mei-Hwa Lee, ve diğerleri
Baskı/Yayın Bilgisi: (2023-04-01)

Knockdown of LncRNA PANDAR by CRISPR-dCas9 Decreases Proliferation and Increases Apoptosis in Oral Squamous Cell Carcinoma
Yazar:: Tingting Jia, ve diğerleri
Baskı/Yayın Bilgisi: (2021-03-01)

Targeting Telomeres and Telomerase: Studies in Aging and Disease Utilizing CRISPR/Cas9 Technology
Yazar:: Andrew C. Brane, ve diğerleri
Baskı/Yayın Bilgisi: (2019-02-01)

Quantitative and modularized CRISPR/dCas9-dCpf1 dual function system in Saccharomyces cerevisiae
Yazar:: Qing Feng, ve diğerleri
Baskı/Yayın Bilgisi: (2023-10-01)

CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cluster for the epothilone production in Myxococcus xanthus
Yazar:: Ran Peng, ve diğerleri
Baskı/Yayın Bilgisi: (2018-01-01)

Precision genome editing in plants: state-of-the-art in CRISPR/Cas9-based genome engineering
Yazar:: Naoki Wada, ve diğerleri
Baskı/Yayın Bilgisi: (2020-05-01)

CRISPR/dCas9-KRAB-Mediated Suppression of <i>S100b</i> Restores p53-Mediated Apoptosis in Melanoma Cells
Yazar:: Samrat Roy Choudhury, ve diğerleri
Baskı/Yayın Bilgisi: (2023-02-01)

CRISPR/dCas13(Rx) Derived RNA N6‐methyladenosine (m6A) Dynamic Modification in Plant
Yazar:: Lu Yu, ve diğerleri
Baskı/Yayın Bilgisi: (2024-10-01)

Bio-SCAN V2: A CRISPR/dCas9-based lateral flow assay for rapid detection of theophylline
Yazar:: Wenjun Jiang, ve diğerleri
Baskı/Yayın Bilgisi: (2023-01-01)

Recent Progress and Future Prospect of CRISPR/Cas-Derived Transcription Activation (CRISPRa) System in Plants
Yazar:: Xiao Ding, ve diğerleri
Baskı/Yayın Bilgisi: (2022-09-01)

Advances and applications of CRISPR/Cas-mediated interference in Escherichia coli
Yazar:: Xiaohui Lim, ve diğerleri
Baskı/Yayın Bilgisi: (2024-03-01)

lncRNA SNHG9 Promotes Cell Proliferation, Migration, and Invasion in Human Hepatocellular Carcinoma Cells by Increasing GSTP1 Methylation, as Revealed by CRISPR-dCas9
Yazar:: Shanting Ye, ve diğerleri
Baskı/Yayın Bilgisi: (2021-04-01)

Utilization of CRISPR-Cas genome editing technology in filamentous fungi: function and advancement potentiality
Yazar:: Qiqing Shen, ve diğerleri
Baskı/Yayın Bilgisi: (2024-03-01)

Kaposi’s Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter
Yazar:: Endrit Elbasani, ve diğerleri
Baskı/Yayın Bilgisi: (2020-08-01)

An Easy and Efficient Strategy for the Enhancement of Epothilone Production Mediated by TALE-TF and CRISPR/dcas9 Systems in Sorangium cellulosum
Yazar:: Wei Ye, ve diğerleri
Baskı/Yayın Bilgisi: (2019-11-01)

Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors
Yazar:: Hong Wang, ve diğerleri
Baskı/Yayın Bilgisi: (2018-06-01)

Tuning dCas9's ability to block transcription enables robust, noiseless knockdown of bacterial genes
Yazar:: Antoine Vigouroux, ve diğerleri
Baskı/Yayın Bilgisi: (2018-03-01)

Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer
Yazar:: Charlene Waryah, ve diğerleri
Baskı/Yayın Bilgisi: (2023-08-01)

CGD: Comprehensive guide designer for CRISPR-Cas systems
Yazar:: A Vipin Menon, ve diğerleri
Baskı/Yayın Bilgisi: (2020-01-01)

Start codon disruption with CRISPR/Cas9 prevents murine Fuchs’ endothelial corneal dystrophy
Yazar:: Hironori Uehara, ve diğerleri
Baskı/Yayın Bilgisi: (2021-06-01)

Harnessing the evolving CRISPR/Cas9 for precision oncology
Yazar:: Tianye Li, ve diğerleri
Baskı/Yayın Bilgisi: (2024-08-01)

Cell Reprogramming With CRISPR/Cas9 Based Transcriptional Regulation Systems
Yazar:: Ksenia M. Shakirova, ve diğerleri
Baskı/Yayın Bilgisi: (2020-07-01)