Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver-Resident Macrophage M2 Polarization via C/EBP Homologous Protein-Mediated Endoplasmic Reticulum Stress

Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver-Resident Macrophage M2 Polarization via C/EBP Homologous Protein-Mediated Endoplasmic Reticulum Stress

Aggravated liver ischemia and reperfusion (IR) injury has been observed in hyperglycemic hosts, but its underlying mechanism remains undefined. Liver-resident macrophages (Kupffer cells, KCs) and endoplasmic reticulum (ER) stress play crucial roles in the pathogenesis of liver IR injury. In this stu...

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Bibliographic Details
Main Authors: Zhuqing Rao, Jie Sun, Xiongxiong Pan, Ziyang Chen, Heliang Sun, Panpan Zhang, Mei Gao, Zhengnian Ding, Cunming Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
liver ischemia and reperfusion
hyperglycemia
macrophage
Kupffer cell
endoplasmic reticulum stress
C/EBP homologous protein
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01299/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01299/full

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