Omega-3 Fatty Acid-Enriched Fish Oil and Selenium Combination Modulates Endoplasmic Reticulum Stress Response Elements and Reverses Acquired Gefitinib Resistance in HCC827 Lung Adenocarcinoma Cells

Omega-3 Fatty Acid-Enriched Fish Oil and Selenium Combination Modulates Endoplasmic Reticulum Stress Response Elements and Reverses Acquired Gefitinib Resistance in HCC827 Lung Adenocarcinoma Cells

Non-small cell lung cancer (NSCLC)-carrying specific epidermal growth factor receptor (EGFR) mutations can be effectively treated by a tyrosine kinase inhibitor such as gefitinib. However, the inevitable development of acquired resistance leads to the eventual failure of therapy. In this study, we s...

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Bibliographic Details
Main Authors: Chien-Huang Liao, Yu-Tien Tzeng, Gi-Ming Lai, Chia-Lun Chang, Ming-Hung Hu, Wei-Lun Tsai, Yun-Ru Liu, Simon Hsia, Shuang-En Chuang, Tzeon-Jye Chiou, Le-Ming Wang, Jacqueline Whang-Peng, Chih-Jung Yao
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Marine Drugs
Subjects:
lung cancer
fish oil
selenium
gefitinib
acquired resistance
Online Access:https://www.mdpi.com/1660-3397/18/8/399

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https://www.mdpi.com/1660-3397/18/8/399

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