Validation of a Microwave-Assisted Derivatization Gas Chromatography-Mass Spectrometry Method for the Quantification of 2-Hydroxybutyrate in Human Serum as an Early Marker of Diabetes Mellitus

Validation of a Microwave-Assisted Derivatization Gas Chromatography-Mass Spectrometry Method for the Quantification of 2-Hydroxybutyrate in Human Serum as an Early Marker of Diabetes Mellitus

Circulating levels of 2-hydroxybutyrate (2HB) are highly related to glycemic status in different metabolomic studies. According to recent evidence, 2HB is an early biomarker of the future development of dysglycemia and type 2 <i>diabetes mellitus</i> and may be causally related to the pr...

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Bibliographic Details
Main Authors: María Rodríguez-García, Guillermo Fernández-Varo, Susana Hidalgo, Gabriela Rodríguez, Irene Martínez, Muling Zeng, Eudald Casals, Manuel Morales-Ruiz, Gregori Casals
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
2-hydroxybutyrate
microwave-assisted derivatization
<i>diabetes mellitus</i>
GC-MS
TMS
human serum
Online Access:https://www.mdpi.com/1420-3049/27/6/1889

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https://www.mdpi.com/1420-3049/27/6/1889

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