Delayed onset, immunomodulation, and lifespan improvement of SOD1G93A mice after intravenous injection of human mesenchymal stem cells derived from adipose tissue

Delayed onset, immunomodulation, and lifespan improvement of SOD1G93A mice after intravenous injection of human mesenchymal stem cells derived from adipose tissue

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective and progressive loss of motor neurons from the spinal cord, brain stem, and motor cortex. Although the hallmark of ALS is motor neuron degeneration, astrocytes, microglia, and T cells actively participa...

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Bibliographic Details
Main Authors: Gabriela Bortolança Chiarotto, Luciana Politti Cartarozzi, Matheus Perez, Ana Laura Midori Rossi Tomiyama, Mateus Vidigal de Castro, Adriana S.S. Duarte, Ângela Cristina Malheiros Luzo, Alexandre Leite Rodrigues de Oliveira
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Brain Research Bulletin
Subjects:
Astrogliosis
Microglial reaction
Synaptic coverage
ALS
SOD1
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923022001447

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http://www.sciencedirect.com/science/article/pii/S0361923022001447

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