Regorafenib induces NOX5-mediated endoplasmic reticulum stress and potentiates the anti-tumor activity of cisplatin in non-small cell lung cancer cells

Regorafenib induces NOX5-mediated endoplasmic reticulum stress and potentiates the anti-tumor activity of cisplatin in non-small cell lung cancer cells

Lung cancer is one of the most commonly diagnosed cancers worldwide. Although cisplatin-based chemotherapy regimens serve a pivotal role in non-small cell lung cancer (NSCLC) treatment, drug resistance and serious side effects limited its further clinical application. Regorafenib, a small-molecule m...

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Bibliographic Details
Main Authors: Hehuan Sui, Sisi Xiao, Suping Jiang, Siyuan Wu, Haizhen Lin, Liyuan Cheng, Lihua Ye, Qi Zhao, Yun Yu, Lu Tao, Feng-Ming Kong, Xiaoying Huang, Ri Cui
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
NSCLC
Regorafenib
Cisplatin
Reactive oxygen species
NOX5
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558623000222

Internet

http://www.sciencedirect.com/science/article/pii/S1476558623000222

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