NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma

NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma

Tumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel r...

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Bibliographic Details
Main Authors: Zhi-Jie Xiao, Jing Liu, Si-Qi Wang, Yun Zhu, Xu-Yuan Gao, Vicky Pui-Chi Tin, Jing Qin, Jun-Wen Wang, Maria Pik Wong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
NFATc2
tumor-initiating cells
SOX2
ALDH1A1
Online Access:https://elifesciences.org/articles/26733

Internet

https://elifesciences.org/articles/26733

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