Sex-specific differences in atherosclerosis, thrombospondin-1, and smooth muscle cell differentiation in metabolic syndrome versus non-metabolic syndrome mice

Sex-specific differences in atherosclerosis, thrombospondin-1, and smooth muscle cell differentiation in metabolic syndrome versus non-metabolic syndrome mice

IntroductionMetabolic syndrome (MetS) amplifies the risks of atherosclerosis. Despite well-known sexual dimorphism in atherosclerosis, underlying mechanisms are poorly understood. Our previous findings highlight a proatherogenic protein, thrombospondin-1 (TSP-1), in hyperglycemia- or hyperleptinemia...

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Bibliographic Details
Main Authors: Shreya Gupta, Saugat Khanal, Neha Bhavnani, Amy Mathias, Jason Lallo, Ariana Kiriakou, Jessica Ferrell, Priya Raman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
TSP-1
metabolic syndrome
SMC differentiation
atherosclerosis
KKAy mice
sex-specific differences
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.1020006/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.1020006/full

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