Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer’s Disease Therapeutic Development

Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer’s Disease Therapeutic Development

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As genome-wide association studies (GWAS) have grown in size, the number of genetic variants that have been associated per disease has correspondingly increased. Despite this increase in the number of single-nucleotide polymorphisms (SNPs) identified per disease, their biological interpretation has...

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Bibliographic Details
Main Authors: Alejo J. Nevado-Holgado, Elena Ribe, Laura Thei, Laura Furlong, Miguel-Angel Mayer, Jie Quan, Jill C. Richardson, Jonathan Cavanagh, NIMA Consortium, Simon Lovestone
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cells
Subjects:
Alzheimer
JAK-STAT
multimodal
genomics
transcriptomics
animal models
Online Access:https://www.mdpi.com/2073-4409/8/5/425

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https://www.mdpi.com/2073-4409/8/5/425

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