Deep mutational scanning of the RNase III-like domain in Trypanosoma brucei RNA editing protein KREPB4

Kinetoplastid pathogens including Trypanosoma brucei, T. cruzi, and Leishmania species, are early diverged, eukaryotic, unicellular parasites. Functional understanding of many proteins from these pathogens has been hampered by limited sequence homology to proteins from other model organisms. Here we...

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Bibliographic Details
Main Authors: Suzanne M. McDermott, Vy Pham, Brian Oliver, Jason Carnes, D. Noah Sather, Kenneth D. Stuart
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1381155/full